Cannabis is regularly find bystudiesto be the least risky unpaid drug and has never been unite to a fatal overdose . Now that that ’s out of the way , let ’s look at a time when scientist at the Johns Hopkins University School of Medicine deliberately give subjects an " acute " dose of THC ( THC ) to learn its effects .

" Cannabis has been historically classified as a psychodelic drug . However , subjective cannabis effects do not typically include psychedelic drug - like burden , " the squad explained in their study .

They also mention that hallucinogenic - comparable result generally happened in unpaid worker who were given purified tetrahydrocannabinol rather than whole - flora marijuana , and face report involving hallucinations tend to pass off in patients with a account of psychosis .

In a double - blind , placebo - controlledstudy , the researchers looked at the effects of expectant venereal disease of gasify tetrahydrocannabinol on military volunteer and compared it to the force of ingesting cannabis , psilocybin , and other psychedelic drug . In the cannabis portion of the field , volunteers fume cannabis that contained either 0 , 10 , or 25   milligrams of THC , run through within 10 instant .

In one volunteer ( the direction of the newspaper due to the outcome it had on him ) the effects of this fortune of the experiment were minimal and included cardiovascular effects as well as a chip of stultification on cognitive tests . However , when he took part in the fourth phase angle of the experimentation – inhaling vaporized hemp that contained 25   mg of THC , the effects were far unassailable , and got progressively worse during the first 20 moment after inhalation .

" He had trouble answer to staff inquiries , was unable to complete self - report questionnaires , had trouble keep his head word up , and appeared to sporadically come asleep or lose consciousness despite encouragement by research staff to persist awake and uphold , " the team indite , add ( belike unnecessarily ) that he " was ineffective to conserve a balanced , stiff gait when he walked . "

The volunteer ,   a 30 - class - old man named H.C. in the paper , had bother staying conscious , though his vital signs remained within normal orbit . For the next few hours , he persist in a state which was n’t ideal for experimenter , given that he was ineffective to perform cognitive tests , and when he could talk it was largely to cover that he felt vile and was experiencing pain and tingling in his branch and neck .

When he was more capable of communicating , a full three 60 minutes after the initial dose , HC reported that he had experienced a number of strange hallucinogenic effect .

" He described visual distortions in the form of the surround and trading floor sinking away and the appearance of radiation pattern moving on the carpet and electric chair in the room , " the team wrote .

" Additionally , he describe an ' out - of - organic structure ' experience characterized by the feeling of being removed from his body , live above it in space , and feel that his environment were sinking away from him , which was also accompanied by a feeling of paralysis , " the paper adds .

After another few hours and some luncheon , these feelings of nausea and dissociation hold out away , and he was able to discharge experiment questionnaires and cognitive tests . Though he reported enceinte changes in the Intensity , Somaesthesia , Perception , and Volition subscales of theHallucinogen Rating Scale(HRS ) , his experience differ from those on other hallucinogenic drugs in terms of noesis and feign .

" feed that changes in affect and cognition are sum features of experience with classic hallucinogen , it is unmanageable to attribute the account causa as an experience interchangeable to that of a unfeigned classic hallucinogenic drug , " the team wrote , observe that it was " curious " that he had not experienced the same effects when smoke whole marihuana with the same dose of THC . The squad believes this could partially be put down to other component in cannabis , smoke or take in at the same time as THC .

" This note is deserving noting as it points to exogenous CB1 sensory receptor agonism as a potential mechanics for bring on delusion , " the team wrote , " and also because it has been postulated that phytocannabinoids such as cannabidiol ( CBD ) or terpenoids that are present in the cannabis plant may mitigate some of the injurious core of THC . "

Anearlier version of this storywas published in April 2023 .