When exposed to catnip or argent vine , cats engage in some fairly predictable behaviors , such as puzzle out and chewing the leaves , rubbing their heads and faces against the plant , and rolling on the ground . qat get a real kick out of these plant , but surprising new enquiry points to a more hardheaded purpose than just wanting to get high .

Nepetalactol — the most potent dynamic constituent in catnip ( Nepeta cataria ) and silver vine ( Actinidia polygama)—provides computed axial tomography with a chemic defense against mosquitoes , according to newresearchpublished in Science Advances . The discovery could explicate why felines , whether domesticated cats or hulking jungle marauder , exhibit exchangeable behaviors after being discover to these plants .

The raw research , direct by Masao Miyazaki from Iwate University in Japan , offers sweet insights into nepetalactol and how it bear upon feline behavior and their opioid sense organ . That nepetalactol deters mosquitoes is a stunning Book of Revelation , and it could result in an entirely novel class of louse repellant , according to the researchers . Nepetalactol had previously been associated with mosquito repellent activeness , but “ our data is the first to show it , ” explain Miyazaki in an e-mail .

A zoned-out cat lying next to some silver vine leaves.

A zoned-out cat lying next to some silver vine leaves.Image: Masao Miyazaki & Reiko Uenoyama

What ’s more , the new newspaper is the “ first to show that nepetalactol is a potent bioactive compound to cats . ” Indeed , it ’s no secret that the chemical has some kind of neurologic essence on computed tomography , but catnip , a plant from the mint family , and silver vine , a kind of kiwifruit , contain a overplus of other bioactive compounds , such as isoiridomyrmecin , iridomyrmecin , isodihydronepetalactone , and dihydronepetalactone . Miyazaki and his co-worker , including researchers from Nagoya University in Japan and the University of Liverpool in the U.K. , focalize on nepetalactol because of its surmise potency .

After amount into middleman with catnip and silver vine , cat engage in some unimaginative behaviour , such as rubbing their head and faces against the plants , twine on the land , and give the mental picture of euphory . This lasts for around five to 15 minutes and is followed by the wreck phase , in which the khat loaf for around an time of day or more . The effect these plants have on cats has been known for century , but scientist do n’t to the full understand the purpose of all this , such as a biological or evolutionary reason for it — assuming it ’s not just some quirky coincidence having to do with the feline brain .

To learn more , the team studied a gang of different felines , including 25 lab cats , 30 savage African tea , and several wrapped big cats , including leopard , jaguars , and catamount . They documented the cat ’ reactions to filter paper laced with nepetalactol . All the cats exhibited the classic behavioral response . Dogs and mice exposed to the chemical substance exhibited no response .

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The scientist also studied the cat ’ reaction to some of the other bioactive agents find in silvern vine and find nepetalactol to be the most potent .

“ This field of study has found that … nepetalactol is the major bioactive compound in the leaves of argent vine that induces characteristic rubbing and rolling in cats , ” write the author in their study . “ Further , nepetalactol had exchangeable bioactivity in Amur leopard , jaguar , and Eurasiatic catamount . As most of the [ feline ] mintage so far tested have shown positive responses toward catmint ( 13 of 21 species test from a total of 41 living species in this family ) , it is likely that this characteristic response to nepetalactol will also be vulgar across many [ felines ] . ”

The group also measure out the cats ’ endorphin levels both before and after exposure , finding that the feline chemical reaction to nepetalactol is regulated by their opioid system ; rarefied storey of endorphins were only notice after exposure to nepetalactol . What ’s more , when the scientists suppress their opioid sense organ with particular drugs , the cats no longer displayed their characteristic demeanour when let out to the chemical .

Argentina’s President Javier Milei (left) and Robert F. Kennedy Jr., holding a chainsaw in a photo posted to Kennedy’s X account on May 27. 2025.

As for silver vine ’s purpose as a potential mosquito repellant , the researchers find that cats with fur covered in nepetalactol attracted importantly few mosquitoes , specifically the species A. albopictus , than the untreated controller radical — in some cases by as much as half .

“ These result show that nepetalactol , shift to confront and head fur by rubbing against eloquent vine leave , functions as a repellent against A. albopictus in cats , ” the writer drop a line . “ This is convincing grounds that the characteristic rubbing and rolling answer office to transplant plant chemicals that allow for mosquito repellency to cats . ”

This , the authors debate , could excuse why the behaviour evolved . The African tea get eminent on these plant life , roll around in the leaves , and unwittingly become protected against mosquitoes in the process . This theory makes a peck of sense , but scientists now require to explicate why this conduct is n’t construe in other creature , and if the repellant action really bechance in nature , not just in a laboratory mount . We also need to determine out if nepetalactol works to gross out A. aegypti , the mosquito responsible for spread out chickenhearted fever , dengue , and Zika .

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Miyazaki allege there might be a very expert understanding why felines have evolved this special relationship with Nepeta cataria and silver vine . Many felid “ rely on stealth to haunt and ambush their prey , ” require them to stay still and still , he said . A repellent that “ reduces their susceptibility to both the botheration of burn mosquitoes and the diseases that these insect vector have a bun in the oven is probable to provide a inviolable selective advantage . ” This explicate why this characteristic has been retained by many cat species , but it “ does not explain why the demeanour has evolved only in felines , ” tell Miyazaki .

https://gizmodo.com/cats-are-happier-and-healthier-when-you-make-them-work-1786057743

One possible account is that an ancestor to forward-looking quat evolve particular olfactory sense organ , which may have been a “ crucial pre - adaptation ” that provided the chance for this behavior to evolve , speculated Miyazaki .

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Looking in the lead , the team wants to identify the olfactory sensory receptor connect to nepetalactol , as well as the genes responsible for for the demeanor . Miyazaki say squad members screen nepetalactol on their weapon , and it appear to keep the mosquito away . But this “ is for letters patent data only , ” he say .

Ah yes , the all-powerful dollar . But this is a case in which good science might lead to a in effect and welcomed commercial-grade production . Indeed , the researchers may have stumbled upon a raw case of mosquito repellant , but meter will tell if it actually works better than established repellent and if it ready economic and hard-nosed sense to synthesise this compound in large batches .

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